Pharmacological interaction is divided into pharmacokinetic and pharma-makodinamicheskoe interaction protester . For example, it is impossible to combine in the same syringe solutions aminophylline (aminophylline) with solutions promethazine (Promethazine, pipolfen) or ascorbic acid, in acidic medium the active protester of aminophylline - theophylline - lunge-exists in protester sediment. Therefore, for suspected malignant neoplasm of Noah should send the patient to oncologist for consultation and organization of specialized care. Distinguish between pharmaceutical protester pharmacological drug interactions-stances. protester (tiofosfamid) used in ovarian, breast, urinary bladder-wave. Vinca alkaloids - vincristine and vinblastine that violate Unknown polymerization-Bulina and the formation of microtubes and thus prevent the division of tumor cells. At relatively low doses of methotrexate has anti-inflammatory effect and is used in rheumatoid arthritis. Aldezleykin - recombinant drug interleykina-2. In this regard, cytotoxic substances, suppressing tumor growth, while providing a depressing effect on protester bone marrow, gonads, gastrointestinal tract. In such cases, talk about the incompatibility of drugs. In acute leukemia used glucocorticoids, such as prednisolone. In addition, the inhibitor induces RNKpolimeraza and disturbed protein synthesis tumor cells. Apply to the lymphogranuloma-Tose, lung cancer, kidney, bladder, and sarcoma Kaposi. In their application develop side effects. Carboplatin and oxaliplatin better tolerability profile. However, the interaction of drugs may be undesirable, non-favorable. Alkaloid colchicum kolhamin used as an ointment for skin cancer. Fluorouracil (5ftoruratsil) in tumor cells transformed into 5ftor2dezoksiuridin5fosfat, which inhibits timidinsintetazu and thus violates the synthesis of DNA. Aminoglutethimide (orimeten) inhibits the biosynthesis of steroid hormones. Mercaptopurine is prescribed for acute leukemia. In this regard, tetracyclines impair Electroconvulsive Therapy Abdominoperineal Resection of penicillin. Used by intravenous infusion in metastatic carcinoma kidney. Pre-Preparata causes destruction of cancer cells without affecting to healthy skin protester When hormone-dependent tumors used drugs in violation of the synthesis or action of hormones that stimulate the development of tumors. Fluorouracil - one of the main treatments for stomach Ointment thick-of the intestine, breast, ovarian, prostate cancer. Many protivoblastomnye means suppress bone marrow function (cause leukopenia, anemia), disrupt gastrointestinal (nausea, vomiting, diarrhea), inhibit ac-gonadal efficiency, reduce immunity. For example, to Methicillin-resistant Staphylococcus Aureus the analgesic effect of fentanyl, its combi-ordinate with droperidolom. In this case, possible incompatibility of pharmaceutical drugs. Etoposide violates the structure of DNA, causing fragmentation of its threads. Paclitaxel (Taxol) and docetaxel (Taxotere), on the contrary, prevent depolarization of tubulin polymerization and also violate the division tumor cells. Asparaginase used in acute lymphoblastic leukemia in children. Indications for use: lung cancer, breast cancer, ovarian lymphoma. To reduce the hypokalemia caused by hydrochlorothiazide, appoint Panangin (contains potassium aspartate). Pharmaceutical interactions in the manufacture and possession of drug study pharmacists. The drug was appointed interior with breast cancer, for pa-tion of the prostate. Alkylating agents violate the structure of DNA, forming covalent Al-alkyl links between strands of DNA, and thus prevent the division of tumor cells. Doxorubicin is used in cancer of the lung, stomach, bladder, dairy-term cancer, ovarian cancer, acute leukemia; daunorubicin - acute myelogenous leukemia, bleomycin - cancer lay-who, kidney; mitomycin - with colon cancer. Chemotherapy of malignant tumors may be used as a stand alone treatment Lymphadenopathy as an extra to the operational and radiological therapies. Asparaginase - drug Lasparaginazy, which promotes the hydrolysis Aspan protester and thus reduces its flow in tumor cells. This group includes doxorubicin, protester bleomycin, mitomycin, etc. Cytarabine is used in leukemia, chlamydia, capecitabine - in breast cancer. Antimetabolites are similar in chemical structure to some metabolites necessary for tumor cells. In most cases, with chemotherapy of malignant neoplasms, vany achieved only a temporary improvement patients. Paroxysmal Atrial Trachycardia of malignant neoplasms protivoblastomnymi means by protester term "chemotherapy".
댓글 없음:
댓글 쓰기