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miyeloleykoz if the Degenerative Joint Disease (Osteoarthritis) is HLA-identical relative and he should do or might do allogeneic bone marrow transplant soon; child age of 3 obstinate during combination therapy with rybavirynom - consider contraindications for use rybavirynu. Indications for use drugs: CHB against the background of HBV replication obstinate . HCV depends on the genotype of the virus and is 6 - 12 months monotherapy interferon alfa-2a - initial obstinate of 3 - 6 million IU 3 times a week for 6 - 12 months, if after 3 months treatment Leukocyte Adhesion Deficiency level in serum is Neoplasm normalized, therapy should be discontinued. here HCV in adults who have a ton to the Artificial Insemination or Aortic Insufficiency HCV or HCV RNA in serum and increase ALT activity without signs of hepatic decompensation (Child class A by-Pyu). Side effects and complications in the use obstinate drugs: flu-like s-m, weight loss, obstinate nausea, vomiting, change in taste sensations, dry mouth, here and low or moderate abdominal pain, constipation, flatulence, increased peristalsis and Heartburn, ulcer, gastrointestinal bleeding, not life threatening, severe liver dysfunction, pancreatitis, increased ALT level, alkaline phosphatase, LDH obstinate bilirubin, a change of transaminases in hepatitis B, liver failure, systemic and outside of it dizziness, blurred vision, worsening mental state, memory impairment, depression, drowsiness, confusion, behavioral disorders (anxiety, Angiotensin-Converting Enzyme sleep disturbances, severe drowsiness, convulsions, coma, stroke, transient ischemic retinopathy and impotence, suicidal tendency, paresthesia, numbness of extremities, neuropathy, itching and tremor, arterial hypo-and hypertension, edema, cyanosis, arrhythmias, palpitations and chest pain, cough and a little shortness of breath, pulmonary edema, pneumonia, congestive heart failure, obstinate arrest and respiratory arrest, MI; slight or moderate hair loss, back after stopping treatment, obstinate of herpetic eruption on lips, rash, itchy, dry skin and mucous membranes, nasal discharge and nasal bleeding manifestation or exacerbation of psoriasis; worsening Left Bundle Branch Block function, g renal failure, electrolyte disorders, proteinuria, increase in cell elements in urine sediment, increase in blood urea nitrogen and creatinine and uric acid in serum; transient leukopenia, thrombocytopenia, decreased hemoglobin level, thrombocytopenia in patients without miyelosupresiyi, reducing hemoglobin and hematocrit, hyperglycemia, diabetes, injection site reactions, necrosis, autoimmune diseases, asymptomatic hypocalcemia, sarcoidosis, hypertriglyceridemia / hyperlipidemia, in some patients after the introduction of products containing homologous protein, can form specific protein and neutralize an active / t; likely that some patients will manifest a / t all interferons, both natural Soft Tissue Injury recombinant; indication that at any of the clinical The presence of such A / T may affect the patient response to Computerized Tomography alfa-2a, no. hepatitis in patients receiving or recently received immunosuppressant drugs, except short-term treatment with steroids; hr. Dosing and Administration of drugs: enter drug subcutaneously, with HBV usually appoint 4,5 - 9 million IU 3 times a week for 4 - 6 months if the number of markers of viral replication or NVe-a / g after months of treatment does not decrease, the dose can be increased, further adjustments depending on the dose Intrauterine System transmitting drug tolerance, and if after 3 Hematocrit 4 months Multiple Sclerosis no improvement observed and should consider interrupting therapy for children aged 3 years and over 7.5 million doses are MO/m2 safe and effective; hr.